Mining Transcriptional Data
Arkady Khodursky, Associate Professor of Biochemistry, Molecular Biology and
Biophysics with the BioTechnology Institute, studies signal processing in relation
to gene position on the chromosome. Through the use of microarray analysis of
E. coli bacteria, Khodursky tries to understand how gene regulation occurs in the
context of the chromosome.
Khodursky has teamed with Jim Cotner (EEB) to utilize microarray technology
to understand the metabolic process controls in hydrogen-producing Cyanobacteria. The primary
hypothesis is that the nature of limiting factors vis-a-vis key ingredients such as CO2, nitrogen, phosphorous, and sulfur has a distinct effect on yield
and energy pathways. The regulatory information obtained on this species of Cyanobacteria should
be applicable to other autotrophic organisms. Systemic understanding of the interactions between
hydrogen metabolism, respiration, photosynthesis and bacterial nutrtional
status is essential to optimizing hydrogen production.
KHODURSKY HOME PAGE
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