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Publications

    2017

  1. Hsu S. et al. (2018) The Five Primer Challenge: an inquiry-based learning module for synthetic biology. In revision.
  2. Hsu S, Smanski MJ (2017) Designing and implementing algorithmic DNA assembly pipelines for multigene systems. In Synthetic Metabolic Pathways, eds Jensen MK, Keasling JD.
    Methods Mol. Biol. ISBN 978-1-4939-7295-1
  3. Maselko M, Heinsch SC, Chacon J, Harcombe W, Smanski MJ (2017) Engineering species-like barriers to sexual reproduction.
    Nat. Comm. 8:883 doi:10.1038/s41467-017-01007-3
  4. Bhatia SP, Smanski MJ, Voigt CA, Densmore DM (2017) Genetic design via combinatorial constraint specification.
    ACS Synth. Biol. doi:10.1021/acssynbio.7b00154
  5. Smanski MJ, Mead D, Gustafsson C, Thomas MG (2017) Meeting Report for Synthetic Biology for Natural Products 2017: The Interface of (Meta)Genomics, Machine Learning, and Natural Product Discovery.
    ACS Synth. Biol. 6:737-743.
  6. Heinsch SC, Otto-Hanson L, Hsu SY, Kinkel L, Smanski MJ (2017) Genome sequences for Streptomyces spp. isolated from disease suppressive soils and long-term ecological research sites.
    ASM Genome Announcements. 5:e00493-17.
  7. 2016

  8. Maselko M, Heinsch SC, Chacon J, Harcombe W, Smanski MJ (2016) "Engineering species-like barriers to sexual reproduction"
    bioRxiv 079095.
  9. Smanski MJ, Zhou H, Claesen J, Shen B, Fischbach MA, Voigt CA (2016) "Synthetic biology to access and expand nature's chemical diversity."
    Nature Reviews Microbiology 14:135-149.
    **Paper selected by Faculty 1000
  10. 2015

  11. Smanski MJ, Schlatter, DC, Kinkel LL (2015) "Leveraging ecological theory to guide natural product discovery."
    Journal of Industrial Microbiology and Biotechnology 43:115-128.
  12. Medema M, et al. (2015) "Minimum information about a biosynthetic gene cluster."
    Nature Chemical Biology 11:625-631.
  13. 2014

  14. Smanski MJ, Bhatia S, Park YJ, Zhao D, Giannoukos G, Ciulla D, Busby M, Calderon J, Nicol R, Gordon DB, Densmore D, Voigt CA (2014) "Functional optimization of gene clusters by combinatorial design and assembly."
    Nature Biotechnology 32:1241-1249.
  15. Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B (2014) "Mechanisms of self-resistance in the platensimycin and platencin producing Streptomyces platensis MA7327 and MA7339 strains."
    Chemistry and Biology 21:389-397.
    **Paper highlighted in The Scientist Magazine: Akst, J (2014) "How a microbe resists its own antibiotics." The Scientist (2/20/2014)
  16. 2013

  17. Yu Z, Rateb ME, Smanski MJ, Peterson RM, Shen B (2013) "Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600."
    Journal of Antibiotics 66:291-294.
  18. 2012

  19. Smanski MJ, Casper J, Peterson RM, Yu Z, Rajski SR, Shen B (2012) "Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners."
    Journal of Natural Products 75:2158-2167.
  20. Smanski MJ, Peterson RM, Shen B (2012) "Platensimycin and platencin biosynthesis in Streptomyces platensis showcasing discovery and characterization of novel diterpene synthases."
    Methods in Enzymology 515:163-186.
  21. Smanski MJ, Peterson RM, Huang S-X, Shen B (2012) "Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis."
    Current Opinions in Chemical Biology 16:132-141.
  22. Smanski MJ, Qu X, Liu W, Shen B (2012) "Biosynthesis of pharmaceutical natural products and their pathway engineering."
    Chapter 4 in Breakthroughs and Perspectives in Organic Chemistry. Ding K, Dai L eds., Wiley-VCH, 125-178.
  23. 2011

  24. Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B (2011) "Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis."
    Proceedings of the National Academy of Sciences USA 108:13498-13503.
    **Paper highlighted in Chemical & Engineering News: Borman, S (2011) Natural product synthases analyzed. C&EN 89:31.
  25. 2010

  26. Chen Y, Smanski MJ, Shen B (2010) "Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation."
    Applied Microbiology and Biotechnology 86:19-25.
  27. Yu Z, Smanski MJ, Peterson RM, Marchillo K, Andes D, Rajski SR, Shen B (2010) "Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners."
    Organic Letters 12:1744-1747.
  28. 2009

  29. Smanski MJ, Peterson RM, Rajski SR, Shen B (2009) "Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin."
    Antimicrobial Agents and Chemotherapy 53:1299-1304.

Patents

  1. Hsu S, Smanski MJ (2016) US. "Recombinant Cells and Methods for Biosynthesis of ENT-Atiserenoic Acid."
    Provisional Patent Application No. 110.05390160. April 25, 2016.
  2. Maselko M, Smanski MJ U.S. "Biocontainment/biocontrol system and methods."
    Provisional Patent Application No. 62/253,954. November 11, 2015.
  3. Zhao D, Voigt CA, Smanski MJ U.S. "Directed evolution of synthetic gene cluster."
    Patent Application No. 61/721188. November 1, 2012.
  4. Shen B, Smanski MJ U.S. "The platensimycin biosynthetic gene cluster of Streptomyces platensis."
    Patent No. US 2009/008161773 A1. March 26, 2009.